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Literature summary for 2.8.2.1 extracted from

  • Arlt, V.M.; Meinl, W.; Florian, S.; Nagy, E.; Barta, F.; Thomann, M.; Mrizova, I.; Krais, A.M.; Liu, M.; Richards, M.; Mirza, A.; Kopka, K.; Phillips, D.H.; Glatt, H.; Stiborova, M.; Schmeiser, H.H.
    Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone (2017), Arch. Toxicol., 91, 1957-1975 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.2.1

Organism

Organism UniProt Comment Textmining
Homo sapiens P50225 isoform SULT1A1
-
Homo sapiens P50226 isoform SULT1A2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + 3-nitrobenzanthrone
-
 Homo sapiens adenosine 3',5'-bisphosphate + N-sulfoxy-3-aminobenzanthrone
-
 ?

Synonyms

Synonyms Comment Organism
SULT1A1
-
 Homo sapiens
SULT1A2
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism no differences are found in in aristolochic acid I-/aristolochic acid II-DNA adduct levels wild-type mice and mice expressing human between isoforms SULT1A1/2 in all tissues analysed including kidney and liver. Sulfation by SULT1A1/2 is important in the activation of 3-nitrobenzanthrone Homo sapiens